Success stories

Bono, the first Hungarian stem-cell treated dog

Bono, a golden retriever was the first dog in Hungary transplanted with stem cells to treat his severe elbow osteoarthritis. He was charming, lively and playful like all puppies, but at the age of six months he started limping more and more frequently. Veterinary examination diagnosed elbow dysplasia, an increasingly common, incurable musculoskeletal disease occurring primarily in irresponsibly bred, full-blood dogs. Unfortunately, the disease developed in both front legs, causing detachment of small cartilage chips that cause pain and inflammation. After the first X-ray examination the veterinarian predicted that within two years Bono would not be able to stand up. What could I do? I could not let Bono live with perpetual pain, and removal of the detached cartilage chips would only have been a temporary solution. Since as a researcher I work with tissue stem cells that can differentiate into cartilage and bone, I decided to try a stem-cell therapy, which had already been used in veterinary and human clinical trials in other countries, such as the USA. Stem cells cultured in our laboratory were injected into the sick elbow joint by Bono’s veterinarian. The result is rousing: since transplantation (2013) Bono has been living without pain, with no medication. It is true that he will never be a frisbee or agility champion, but he feels good and lives a nearly full life.

Éva, Bono’s owner

Luna and the elbow dysplasia

Luna and Lolita were born in March 2012 and came to us when they were 8 weeks old. They belong to our little family of four like a fifth and a sixth cog. We tried to take really good care of them, but we were quite inexperienced. The elbow pain the darker-colored dog suffered from was already apparent in the first winter of her life, and, by next spring, she had serious difficulties standing up (the cheerful, always lively puppy turned into a bad-tempered, hardly moving pup), while the other puppy was growing healthily. As recommended by others, we contacted veterinarian Dr. Ottó Sebő in Makó, who operated on both elbow joints of Luna in the early summer of 2014. Following surgery, Luna recovered rapidly, and, for approximately half a year, there were no problems, but, after that, pain in the legs and difficulties standing up recurred. At the vet’s suggestion, we joined the Stem CellX (mesenchymal stem cell) transplantation program with great expectations and fear.

From the third month following the transplantation, Luna has been the totally symptom-free, smiling doggie she once was. Just like her naughty sister, she has become a happy, extremely playful team member of our family (showing almost human characteristics). She has no difficulty whatsoever in moving; she swims very well, (while Lolita can only paddle). They race across the garden in huge leaps and wrestle, and, though they own the whole court, our garden remains awesome, and we love them for that. We hope Luna will remain healthy and happy all her life, and we owe many thanks to Stem CellX for this opportunity!

Luna’s owner

Quickie

I am very pleased to report two successes within one story. The first is the opportunity itself that I as a biologist can help animals who have joint problems. The second is that I successfully treated my own dog with MSC from adipose tissue. Our actively training, reckless 6-year-old miniature spitz had a torn anterior cruciate ligament on his left hind leg, and was treated with stem cells after surgery to accelerate healing and to regenerate damaged tissues. Hopping on three legs overstrains the joint of the other leg and may also lead to ligament injuries and abrasion, which was prevented by the treatment. Now we can go to do the usual kilometers again, and continue an active, athletic life.

Marietta, Quickie’s owner

Málna

Stem cells were injected into the joints of Málna, a young English Bulldog, to promote regeneration following cartilage tear. Ever since, she has been speeding with an energy exceeding that of her breed.

Csilla, Málna’s owner